Cortisone Injection

Cortisone is a hormone released by the adrenal gland in response to stress. It is a potent anti-inflammatory agent. Synthetically produced cortisone is more potent and longer acting than natural cortisone and is used for diagnosis as well as treatment of a variety of musculoskeletal conditions such as osteoarthritis, bursitis and tendinopathy.

Cortisone injections produce a significant reduction in pain and inflammation in most cases. The duration and degree of the beneficial effect can vary from patient to patient. It takes about 2 to 3 days for the cortisone injection to produce any effect. In some individuals, these injections may not produce any effect. We recommend no more than 3 injections to one area over the course of a year however, generally it is more often the case that if the condition is amenable to cortisone injection only one injection is required.

After the procedure

You may experience pain at the site of the injection once the effect of the local anaesthetic wears off. The pain may last for up to 48 hours. On average cortisone requires about 36 hours to initiate its action. However, this duration may vary among different patients.

Side effects and complications

The most common side effect of cortisone injection is a “cortisone flare”, a condition where cortisone crystallizes in the injected area and causes severe pain. It usually occurs in the first 24-48 hours after the injection and lasts for a couple of days. It can be managed with the help of ice packs and analgesics. Other adverse effects associated with cortisone injection may include:

  • Infection at the injection site: It is a rare but serious complication and may be associated with fever along with pain and swelling at the injection site. Antibiotics may be prescribed for the management of infection.
  • Transient elevation in blood sugar in patients with insulin dependent diabetes: This may last for up to 10 days. Diabetics should consult their doctor before the procedure for temporary modification of their medication.
  • Redness and flushing of the face: This may occur on the second or third day of the procedure and may last for about 7 days. Antihistamines can be used if the redness fails to resolve.
  • Superficial injection may be associated with localised skin and subcutaneous fat atrophy as well as hypo-pigmentation (whitening of the skin) at the injected site
  • Prolonged high dose steroid therapy may be associated with avascular necrosis of the head of the femur or humerus.

In case of any adverse reaction contact your doctor immediately.


The Stadium Clinic acknowledges the Gadigal people of the Eora Nation as the traditional custodians of the land on which we are fortunate to work and live, and we recognise their continuing connection to land, water, and community.